- Introduction
Evodiamine is a naturally occurring indole alkaloid that serves as the predominant bioactive ingredient of the traditional Chinese medicine Evodia rutaecarpa. Its pharmacological profile is broad, encompassing hypertensive, antitumor, cardioprotective, weight-reducing, anti-inflammatory, analgesic, and anti-Alzheimer’s properties. As an emerging natural anticancer agent, evodiamine suppresses the growth of a wide array of tumor cells, including those of cervical, colon, lung, melanoma, T‑lymphocytic leukemia, prostate, and breast cancers. Additional biological effects include thermoregulation, antihypoxia, dermatological benefits, bronchoconstriction, and hormone secretion modulation. Moreover, evodiamine displays a strong affinity for multiple proteins, enabling it to act as a multi‑target compound with diverse physiological activities.
- Basic Information
Product Name: Evodiamine Reddit Powder
Specification: 98% evodiamine
Appearance: Off‑white to pale yellow solid
CAS Number: 518‑17‑2
Molecular Weight: 303.36
Molecular Formula: C₁₉H₁₇N₃O
Melting Point: 278 °C
Solubility: Soluble in acetone; sparingly soluble in ethanol, ether, and chloroform; practically insoluble in water, petroleum ether, and benzene
- Benefits and Functions of Evodiamine Reddit
3.1 Antitumor Activity
Evodiamine curbs the proliferation of various cancer cell lines—cervical, colon, lung, melanoma, T‑lymphocytic leukemia, prostate, and breast cancers—by promoting anti‑proliferative and pro‑apoptotic effects. It additionally impedes tumor invasion and metastasis.
3.2 Anti‑Dementia Effects (Alzheimer’s Disease)
Studies indicate that evodiamine enhances glucose uptake in brain tissue and inhibits inflammatory cytokines without affecting amyloid‑beta deposition. Its improvement in behavioral outcomes of Alzheimer’s mouse models is therefore believed to stem from anti‑inflammatory actions. Dehydroevodiamine, a structurally related isoform, has shown even more potent anti‑Alzheimer’s effects, and its chemical scaffold has been employed in the clinical design of new cholinesterase inhibitors.
3.3 Influence on the Endocrine System
Evodiamine suppresses steroidogenic enzymes such as 3β‑hydroxysteroid dehydrogenase (3β‑HSD) by attenuating intracellular cAMP‑dependent pathways, reducing StAR protein expression and signal transduction, and directly inhibiting corticosterone release in rat adrenal cortex reticularis cells. Incubation of rat testicular interstitial cells (TICs) with 10⁻⁴ mol/L evodiamine for 1, 2, and 4 hours substantially lowered basal testosterone levels, human chorionic gonadotropin‑stimulated testosterone secretion, and forskolin‑induced testosterone release. It also inhibited testosterone release triggered by 8‑Br‑cAMP and androstenedione.
3.4 Hypoglycemic and Anti‑Obesity Effects
Evodiamine decreases serum total cholesterol and triglyceride levels in obese individuals and can reverse vascular hypertrophy associated with obesity complications. Its mechanism likely involves the regulation of CGRP and TRPV1 expression in serum, vascular tissue, and dorsal root ganglia.
3.5 Cardiovascular Effects
Evodiamine produces both indirect excitatory and direct inhibitory actions on cardiac tissues. Its blood‑pressure‑lowering effect is achieved through the relaxation of endothelial and smooth muscle cells, while it also influences aldosterone release by inhibiting 11‑hydroxylase, an enzyme involved in aldosterone steroidogenesis, thereby modulating blood pressure. Methanolic extracts of Evodia and specific quinolone alkaloids markedly diminish vascular tone and help regulate blood pressure.
- Applications
4.1 Weight Loss
Evodiamine not only stimulates calorie burning but also hinders the formation of new fat cells. Research shows it reduces the differentiation of preadipocytes. It is especially valued in dietary supplements (notably fat burners) because it elevates body temperature—for instance, through thermogenesis prior to exercise—allowing the body to incinerate more calories and ultimately foster weight loss.
4.2 Anti‑Inflammatory Pharmaceuticals
Evodiamine dose‑dependently suppresses the expression of COX‑2 and inducible nitric oxide synthase (iNOS), lowering prostaglandin E₂ release. It significantly diminishes the number of writhes induced by acetic acid. In isolated mouse ileum, evodiamine eliminated the response to sensory nerve stimulation while preserving the vagal nerve response, demonstrating analgesic effects through sensory nerve desensitization.
4.3 Cosmetics and Beauty
Evodiamine activates skin microcirculation, delivering a revitalized, radiant complexion. It is a powerful anti‑inflammatory, soothing irritated, sensitive skin and reducing redness. It may also diminish the skin’s sensitivity to environmental stress and pollution.
- Certificate of Analysis
| Analysis Items | Specifications | Test Methods |
|---|---|---|
| Appearance & Color | Fine brown‑yellow powder | Visual |
| Odor & Taste | Characteristic | Organoleptic |
| Mesh Size | NLT 90% through 80 mesh | 80 Mesh Screen |
| Assay (HPLC) | ≥98% Evodiamine | 98.12% (HPLC) |
| Extraction Method | Hydro‑alcoholic | / |
| Extract Solvent | Grain alcohol / Water | / |
| Moisture Content | NMT 5.0% | 5 g / 105 °C / 2 hrs |
| Ash Content | NMT 5.0% | 2 g / 525 °C / 3 hrs |
| Heavy Metals | NMT 10 ppm | Atomic Absorption |
| Arsenic (As) | NMT 1 ppm | Atomic Absorption |
| Cadmium (Cd) | NMT 1 ppm | Atomic Absorption |
| Mercury (Hg) | NMT 0.1 ppm | Atomic Absorption |
| Lead (Pb) | NMT 3 ppm | Atomic Absorption |
| Sterilization Method | High temperature & high pressure shortly (5″–10″) | |
| Total Plate Count | NMT 10,000 cfu/g | / |
| Total Yeast & Mold | NMT 1,000 cfu/g | / |
| E. Coli | Negative | / |
| Salmonella | Negative | / |
| Staphylococcus | Negative | / |
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Plant Extract Supply is a manufacturer with more than 17 years of experience exporting herbal extract powders from China.
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We provide competitively priced products supported by third‑party inspection reports to guarantee safety for use anywhere in the world. If you are not completely satisfied with your order, we offer hassle‑free returns and exchanges.
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Where to Buy Evodiamine Reddit?
Simply email [email protected] or submit your request using the form below. We are available to assist you at any time!
