Lupeol Extract – High-Purity Botanical Triterpenoid for Advanced Research and Formulation
Lupeol Extract is a naturally derived, pentacyclic triterpenoid sourced from a wide range of fruits, vegetables, and medicinal botanicals, including strawberries, mangoes, grapes, olives, lupine seed coats, fig latex, and various Chinese herbal preparations. With a molecular formula of C₃₀H₅₀O and a molecular weight of 426.73 g/mol, this white to off-white powder is standardized to a potent 8% lupeol content, allowing researchers and product developers to harness its multifaceted bioactivity in a consistent, traceable form.
Botanical Origin and Chemical Identity
Lupeol belongs to the lupane family of triterpenes. It is abundant in the cuticular waxes of many edible plants and in the latex of select species. Its pentacyclic structure and three-anvil carbon skeleton underpin its stability and diverse pharmacological interactions. The extract is rigorously standardized so that every batch preserves the full spectrum of native co-constituents alongside the defined lupeol percentage, ensuring reproducible performance in preclinical and applied settings.
Product Specifications
| Parameter | Value |
|---|---|
| Product Name | Lupeol Extract |
| Specification | 8% (HPLC) |
| Appearance | White to off‑white powder |
| CAS No. | 545-47-1 |
| Molecular Formula | C₃₀H₅₀O |
| Molecular Weight | 426.73 g/mol |
| EINECS No. | 208-889-9 |
| Melting Point | 215 °C |
| Boiling Point | ~482.1 °C (estimated) |
Pharmacological and Therapeutic Potential
Lupeol has been extensively studied for its powerful anti-inflammatory and antioxidant capacities, as well as its ability to accelerate wound healing by modulating pro‑inflammatory cytokines and oxidative stress. More prominently, a growing body of in vitro and in vivo research highlights its anti‑tumor properties across multiple cancer types, making it a promising lead compound for oncological investigation.
Key Research Findings – Anti‑Tumor Activity
- Melanoma: Suppressed growth and induced cellular differentiation in murine melanoma models.
- Skin Cancer: Inhibited tumor development and reduced the expression of tumor markers in mouse skin cancer studies.
- Breast Cancer: Demonstrated a direct inhibitory effect on the proliferation of breast cancer cells.
- Prostate Cancer: Triggered apoptosis and significantly restrained prostate cancer cell growth.
- Pancreatic Cancer: Blocked the Ras signaling pathway, thereby promoting apoptosis in pancreatic cancer cells.
- Hepatocellular Carcinoma: Diminished the self‑renewal capacity of liver tumor‑initiating cells both in vitro and in vivo.
- Leukemia: Exerted growth‑inhibitory and apoptosis‑inducing effects, with activity correlated to the carbonylation of the lupane skeleton.
- Head & Neck and Ovarian Cancers: Showed meaningful inhibitory effects in human head and neck tumor lines as well as ovarian cancer cells.
Beyond oncology, lupeol’s anti‑inflammatory action operates through the downregulation of NF‑κB and COX‑2 pathways, while its antioxidant profile is linked to robust free‑radical scavenging and the preservation of endogenous antioxidant enzyme systems. These mechanisms explain its potential in managing chronic inflammatory conditions, arthritis, and oxidative stress‑related disorders.
Applications
- Pharmaceutical Research: Used as a reference standard, pharmacological tool, and lead molecule in the development of therapies for leukemia, pancreatic, breast, prostate, liver, and other cancers.
- Transplant Medicine: Investigated for the prevention of acute graft‑versus‑host disease (GVHD) following bone marrow transplantation.
- Nutraceutical Formulations: Incorporated into dietary supplements for its antimutagenic, anti‑arthritic, and overall cellular health benefits.
- Cosmetic and Personal Care: Valued for its antioxidant and anti‑inflammatory properties, making it suitable for anti‑aging, soothing, and reparative skincare products.
- Analytical and Quality Control: Employed for content determination, identity testing, and pharmacological experiments.
Why Source Your Lupeol Extract from Plant Extract Supply
Plant Extract Supply is a highly experienced, vertically integrated manufacturer with over 17 years of expertise in producing premium botanical extracts, fine chemicals, and active pharmaceutical ingredients. Our two state‑of‑the‑art facilities, encompassing a combined 40,000 m² near the botanically rich Qinling Mountains in Shaanxi, China, provide direct access to superior raw materials and enable end‑to‑end quality control.
Every batch is produced in strict compliance with GMP, HACCP, ISO, EU and USDA organic, Kosher, Halal, and FDA registration standards. Our commitment to transparency means we provide third‑party inspection reports and fully traceable documentation, ensuring that you receive a safe, authentic, and consistent product anywhere in the world. With more than 300 items held in safety stock, we can promptly fulfill both small‑scale research requests and large‑scale commercial orders. Should any verified quality concern arise, we offer immediate replacement or refund without unnecessary delays.
Sample Availability and Ordering
We understand the importance of validation before commitment. Free samples of our Lupeol Extract are available for your evaluation. The typical minimum order quantity starts at just 10 g for high‑value extracts, and we are always pleased to provide volume‑based pricing on larger quantities.
Get in touch today to request a sample or discuss your specific formulation needs. Our specialists are ready to support your innovation.
Lupeol Extract – in stock now. Reach out to receive your sample and take the next step in your development journey.
