PRODUCT OVERVIEW
Rotundine Powder is a purified, crystalline alkaloid recognized chemically as 2,3,9,10-tetramethoxy-5,8,13,13a-tetrahydro-6H-dibenzo[a,g]quinolizine (CAS No. 10097-84-4). With the molecular formula C21H25NO4 and a molecular weight of 355.43 g/mol, this active pharmaceutical ingredient (API) serves as a non-narcotic analgesic and sedative. Clinically, it is valued for its multifaceted therapeutic profile, offering relief from visceral pain including gastric and duodenal ulcer discomfort, dysmenorrhea, postpartum contraction pain, nervous insomnia, and spasmodic cough. Its mechanism is distinct from opioid analgesics, providing effective symptom management without the risk of respiratory depression at standard therapeutic doses.
PRODUCT SPECIFICATIONS
| Attribute | Description |
|---|---|
| Product Name | Rotundine Powder |
| Purity (Assay) | 98% (HPLC) |
| Physical Form | White to Off-White Crystalline Powder |
| Particle Size | 80 Mesh |
| Molecular Formula | C21H25NO4 |
| Molecular Weight | 355.43 g/mol |
| CAS Registry Number | 10097-84-4 |
| Manufacturing Process | Precision Chemical Synthesis |
| Solubility Profile | Freely soluble in chloroform; slightly soluble in ethanol and ether; practically insoluble in water; soluble in dilute sulfuric acid |
PHARMACOLOGICAL ACTION & EFFICACY
Rotundine’s therapeutic value is derived from its unique interaction with central dopamine receptors, distinguishing it from conventional analgesics.
1. Central Analgesic, Sedative, and Hypnotic Properties
Rotundine exerts a pronounced analgesic effect that is clinically superior to standard over-the-counter antipyretics, yet it does not carry the abuse liability or severe side-effect profile of narcotics like pethidine. Its primary clinical utility is in managing chronic, persistent pain and dull visceral pain. Crucially, it does not induce respiratory depression or gastrointestinal smooth muscle spasm at therapeutic levels. The concurrent sedative and hypnotic action makes it particularly effective for pain syndromes complicated by nervous insomnia. The mechanism is hypothesized to involve the inhibition of the brainstem reticular activating system, likely through dopamine receptor antagonism, though research into its full pharmacodynamics is ongoing. Notably, therapeutic administration is not associated with physical dependence.
2. Neuroprotective Effects Against Cerebral Ischemia-Reperfusion Injury
Beyond analgesia, preclinical research has demonstrated significant neuroprotective capabilities. Studies indicate that Rotundine can markedly extend survival time in cerebral ischemic models. Its protective action is linked to enhancing the endogenous antioxidant defense system—upregulating superoxide dismutase (SOD) and lactate dehydrogenase (LDH) activity—while concurrently attenuating oxidative stress markers such as malondialdehyde (MDA) and nitric oxide (NO) in brain tissue. This profile suggests a capacity to mitigate lipid peroxidation damage following ischemic events.
PRIMARY APPLICATIONS
- Active Pharmaceutical Ingredient (API): Formulated into analgesic and sedative medications for oral administration.
- Therapeutic Intermediate: Utilized in the synthesis of novel compounds targeting pain, mood disorders, and neuroprotection.
- Clinical Research: Investigated for its role in managing functional pain syndromes, sleep disorders, and as an adjuvant therapy in cerebral vascular health.
SUPPLY CHAIN EXCELLENCE BY PLANT EXTRACT SUPPLY
Plant Extract Supply stands as a premier, vertically integrated manufacturer of fine chemical and botanical derivatives, grounded in over 17 years of industry expertise. Our operations are anchored in a commitment to producing high-quality, sustainable ingredients that advance human health.
Infrastructure and Sourcing Integrity
Our manufacturing capabilities are centralized across two state-of-the-art facilities encompassing a total area of 40,000 square meters in Xi’an, Shaanxi Province. Our strategic location adjacent to the Qinling Mountains—a globally recognized biodiversity hotspot—ensures privileged access to an unparalleled reservoir of premium, authentic raw botanical materials.
Uncompromising Quality Assurance
Every batch of Rotundine Powder is produced under a rigorous, standardized protocol that strictly adheres to Good Manufacturing Practices (GMP). Our quality management system is reinforced by a comprehensive portfolio of international certifications, including HACCP, ISO, EU and USDA Organic, SC, and SGS auditing. We further guarantee compliance with Kosher, Halal, and FDA registration standards for our facility, ensuring our product meets the most demanding global regulatory requirements.
Client-Centric Engagement
We prioritize transparency and customer confidence. We offer competitively priced, 100% tested products, each accompanied by a definitive third-party Certificate of Analysis to verify purity and safety. Our large, diversified inventory of over 300 products allows for immediate dispatch of free evaluation samples. We back our quality with an unconditional guarantee: if a confirmed quality discrepancy arises from our side, we will immediately replace the product or provide a full refund.
FREQUENTLY ASKED QUESTIONS
Q: What is the standard procedure for quality verification before bulk purchase?
A: We provide free existing samples for your initial evaluation. Alternatively, we can produce a pre-shipment sample tailored precisely to your specifications, allowing you to confirm all parameters before dispatching a commercial order.
Q: What is the Minimum Order Quantity (MOQ)?
A: Our standard MOQ is 10 grams. For high-potency, high-value products, the MOQ may be as low as 1 gram. For lower-value commodities, an MOQ of 100 grams typically applies. We strive to accommodate diverse project scales from R&D to commercial production.
Q: Are volume-based discounts available?
A: Absolutely. We have a tiered pricing structure that provides increasingly competitive rates for larger quantities. Please contact our sales team with your projected annual volume for a tailored quotation.
Q: How does Plant Extract Supply manage quality complaints?
A: Customer satisfaction is paramount. Should a quality issue be confirmed through our mutual investigation as originating from our facility or process, we will take immediate corrective action through either replacement of the goods or a full payment refund.
GLOBAL TRADE ENGAGEMENT
We actively participate in leading international trade exhibitions, providing a platform for in-person dialogue with our technical and commercial experts. We welcome the opportunity to discuss your specific requirements and explore how Plant Extract Supply can be a trusted partner in your supply chain.
