- Introduction of Stephania Extract
Stephania extract is a bisbenzylisoquinoline alkaloid derived from plants belonging to the Antibiotics family. It possesses anti-tumor, anti-malarial, antibacterial, and immune-modulating activities. Modern studies show that it can stimulate the reticuloendothelial system, activate hematopoietic tissue, and encourage bone marrow proliferation. Clinically, it is used to prevent leukopenia in cancer patients caused by radiotherapy and chemotherapy, achieving measurable benefits. It can partially reverse multidrug resistance in leukemia cells, outperforming the classic reversal agent verapamil while exerting far lower cytotoxicity at the reversal dose. International research has also demonstrated that cepharanthine effectively reverses resistance in several drug-resistant cell lines. In vivo, it enhances the immune function of cells and macrophages. In Japan, cepharanthine has been employed as a leukocyte-elevating medication for over a year with no significant toxic side effects, while in China it has been used for many years in the experimental treatment of pneumoconiosis. These findings underline the remarkable clinical value of cepharanthine.
- Basic Information
Product name: Stephania extract
Specification: 98%
Appearance: Pale yellow
CAS Number: 481-49-2
Molecular Weight: 606.71
Molecular Formula: C37H38N2O6
Melting Point: 145–155°C
Solubility: Soluble in acetic acid; can be hydrogenated under palladium catalysis
- Benefits and Functions
3.1 Antitumor effects
Stephania extract offers significant antitumor potential. Cepharanthine alone can inhibit tumor cell proliferation and strengthen the body’s immunity to combat cancer. More promisingly, when combined with chemotherapeutic drugs, cepharanthine enhances chemotherapy efficacy by reducing cellular resistance. The main mechanism appears to involve interference with plasma membrane function, leading to increased intracellular accumulation of anticancer agents. Additionally, cepharanthine sensitizes tumor cells to radiotherapy.
3.2 Supporting breastfeeding in women
Historically, Stephania extract was recognized as a remedy to induce labor. As its use spread eastward, it appeared in Traditional Chinese Medicine texts for addressing abdominal pain, menstrual cramps, and swelling.
3.3 White blood cell boosting
It acts as a leukoproliferative agent that promotes bone marrow tissue proliferation, thereby raising white blood cell counts. It is indicated for leukopenia. It can increase peripheral blood leukocytes, and animal experiments show it significantly prevents mitomycin-induced leukopenia without compromising mitomycin’s anticancer activity. Its mechanism involves fostering bone marrow proliferation to produce an elevated leukocyte effect. It is used for granulocyte deficiency resulting from tumor chemotherapy and radiotherapy, as well as leukopenia from other causes.
- Applications
4.1 Serves as an analgesic.
4.2 Can be used as a leukocyte proliferation promoter in leukopenia. It elevates peripheral white blood cell levels. Animal studies confirm that it notably prevents mitomycin-induced leukopenia while preserving the anticancer action of mitomycin. Mild gastrointestinal reactions such as nausea, vomiting, and diarrhea may occur occasionally.
- Certificate of Analysis
Product Name: Stephania extract
Batch Number: FD20110901
Batch Quantity: 125 kg
Analysis Date: 2021/11/15
Manufacture Date: 2021/11/09
Expiry Date: 2023/11/08
| Items | Standards | Results |
| Specification(HPLC) | Cepharanthine≥98% | 99.38% |
| Physical Description | ||
| Description | Light Yellow to White Powder | Complies |
| Odor | Characteristic | Complies |
| Taste | Characteristic | Complies |
| Particle size | 95% pass 80 mesh | Complies |
| Ash | ≤2.0% | 0.0076% |
| Loss on Drying | ≤5.0% | 1.04% |
| Chemical Tests | ||
| Heavy metals | ≤10ppm | Complies |
| Pb | ≤2ppm | Complies |
| As | ≤2ppm | Complies |
| Cd | ≤0.5ppm | Complies |
| Hg | ≤0.1ppm | Complies |
| Residue on Ignition | Eur.Pharm | Complies |
| Microbial | ||
| Total Plate Count | ≤5000cfu/g | Complies |
| Yeast＆Mould | ≤100cfu/g | Complies |
| Staphylococcus | Negative | Complies |
| Conclusion | Conform to specification. |
The Best Stephania Extract Supplier
Plant Extract Supply is a manufacturer with over 17 years of experience exporting herbal extract powder from China.
Plant Extract Supply is a leading enterprise dedicated to the research, development, production, sales, and service of cosmetic ingredients, healthcare ingredients, fruit and vegetable powders, food additives, active pharmaceutical ingredients (APIs), and traditional Chinese medicine raw materials. We insist on producing high-quality, eco-friendly products for human health and building mutually beneficial, win-win partnerships as our core strategy.
Plant Extract Supply operates two factories covering a total area of approximately 40,000 square meters in Xi’an, Shaanxi, China, with convenient transportation. The facilities are close to the botanically rich Qinling Mountains, a treasure trove of unique plant resources, ensuring access to premium raw materials.
Why Choose Plant Extract Supply’s Stephania Extract?
From raw material selection and extraction to finished product, we manufacture standardized plant extracts strictly in accordance with GMP, HACCP, EU and USDA organic standards, ISO, SC, and SGS requirements. Our products comply with Kosher and Halal certifications and are registered with the FDA.
We deliver competitively priced products with third-party inspection reports to guarantee global safety. If you are not fully satisfied, we provide hassle-free returns and exchanges.
Plant Extract Supply keeps over 300 products in stock, and free samples can be dispatched immediately.
Where to Buy Stephania Extract?
Simply email [email protected] or submit your requirements in the form below. We are at your service anytime!
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