Artesunate Functional Ingredient Supplier

Artesunate

1. Introduction to Artesunate Powder

Artesunate is a fast-acting antimalarial agent effective against Plasmodium vivax and chloroquine-resistant Plasmodium falciparum. It rapidly controls acute malaria attacks and is used to treat severe cases such as cerebral and jaundiced malaria.

2. Basic Information

Product Name	Artesunate
Specification	98%
Appearance	White powder
CAS Number	88495-63-0
Molecular Weight	384.42
Molecular Formula	C₁₉H₂₈O₈
Melting Point	132-135°C
Solubility	Soluble in acetic acid, hydrogenates under palladium catalysis

3. Benefits and Functions

3.1. Antimalarial Properties

Artesunate is a sesquiterpene lactone derivative of artemisinin, exhibiting stronger antimalarial effects than its parent compound. It effectively targets asexual Plasmodium parasites, rapidly alleviating malaria symptoms, including cerebral malaria. However, it does not affect P. falciparum gametocytes.

While highly effective, it may have a high relapse rate. At therapeutic doses, side effects are rare, though high doses may temporarily reduce reticulocyte levels (reversible upon discontinuation). Use in early pregnancy requires caution due to insufficient teratogenicity data.

3.2. Antitumor Potential

Research suggests artesunate possesses tumoricidal properties with low resistance risk. It inhibits cancer cell proliferation, induces apoptosis, disrupts tumor vascularization, and enhances chemotherapy efficacy.

4. Applications

4.1. Clinical Use

As the only water-soluble artemisinin derivative, artesunate is a first-line treatment for severe malaria, especially chloroquine-resistant strains. It rapidly reduces fever, clears parasites, and has minimal side effects.