Natural Hirudin is the most extensively researched and potent component among the numerous bioactive compounds derived from leeches and their salivary glands. It is a small peptide composed of 65–66 amino acids. Hirudin powerfully inhibits thrombin and remains the most potent natural specific thrombin inhibitor discovered to date.
Product Name: Hirudin
Specification: 300/800 ATU/G
Appearance: White powder
CAS No.: 113274-56-9
Molecular formula: C66H93N13O25
Molecular weight: 1468.52
Boiling point: 1913.6±65.0 °C (Predicted)
Density: 1.384±0.06 g/cm³ (Predicted)
Anticoagulant Effect
Natural Hirudin exerts a highly specific and efficient inhibition on thrombin. It directly blocks thrombin and disrupts its proteolytic activity, delivering powerful anticoagulant action. Compared to heparin, it requires a much lower dose, does not cause bleeding, and functions independently of endogenous cofactors.
Anti-thrombotic Effects
Improving Microcirculation and Promoting Metabolism
It reduces inflammation and edema surrounding brain tissue, alleviates elevated intracranial pressure, improves local circulation, and supports neurological recovery. Additionally, it promotes the absorption of experimental ear hematomas.
Improvement of Cholesterol and Triglycerides
Leech-derived substances significantly lower cholesterol and triglyceride levels in experimental hyperlipidemia. Hirudin suppresses tumor cell growth, including inhibition of liver cancer. Owing to its strong anticoagulant properties, it facilitates the infiltration of anticancer drugs and immune-active cells into tumor tissues, helping to destroy cancer cells.
Anti-myocardial Ischemia and Tardive Dyskinesia
Its aqueous extract markedly counteracts acute myocardial ischemia and arrhythmia. Intraperitoneal injection of leech-derived compounds increases nutritional blood flow. Hirudin solution administered for sedation helps reduce atrial fibrillation and peripheral inflammatory responses; similar benefits have been observed in subcutaneous hematoma experiments.
Effects on Diabetes Mellitus and Its Complications
Insulin resistance affects over 90% of patients with type II diabetes. Hirudin acts as an insulin sensitizer, enhancing the body’s sensitivity to its own insulin and reactivating insulin’s blood sugar-lowering function. Diabetes often damages blood vessel walls, triggers inflammation, and promotes clot formation, leading to complications such as necrosis in the eyes, kidneys, and lower extremities. Hirudin mitigates vascular wall inflammation and helps prevent thrombosis.
Natural Hirudin represents a promising class of anticoagulant and anti-thrombotic agents. It can be used to treat various thrombotic conditions, especially venous thrombosis and disseminated intravascular coagulation. It also helps prevent post-surgical arterial clot formation, as well as re-thrombosis after clot dissolution or revascularization. Moreover, it improves outcomes in extracorporeal circulation and hemodialysis. In microsurgery, where vascular embolisms at anastomosis sites often cause failure, hirudin promotes wound healing. Research further shows that hirudin plays a role in tumor treatment by halting the metastasis of cancer cells. It has demonstrated efficacy against fibrosarcoma, osteosarcoma, angiosarcoma, melanoma, and leukemia. When combined with chemotherapy and radiotherapy, hirudin enhances therapeutic effectiveness by increasing blood flow within the tumor.
ADVANTAGES
1. Premium Supplier
Plant Extract Supply is a manufacturer with over 17 years of experience exporting herbal extract powder in China.
Plant Extract Supply is a leading manufacturer dedicated to the research, development, production, sales, and service of cosmetic ingredients, healthcare ingredients, fruit and vegetable powders, food additives, active pharmaceutical ingredients (API), and raw materials for traditional Chinese medicine. We are committed to producing high-quality, eco-friendly products for human health. Our development strategy centers on building mutually beneficial, win-win partnerships.
We operate two factories with a total area of approximately 40,000 square meters in Xi’an, Shaanxi, China, enjoying convenient transportation. The facilities are located near the botanically rich Qinling Mountains—a treasury of unique plant resources—giving us direct access to premium raw materials.
2. Why Choose Plant Extract Supply
From raw material selection and extraction to finished products, we manufacture standardized plant extracts in strict compliance with GMP standards, HACCP, EU and USDA organic regulations, ISO, SC, and SGS requirements. Our products comply with Kosher, Halal, and are FDA-registered.
We offer competitively priced products accompanied by third-party inspection reports to ensure their safety for global use. If you are not completely satisfied with your order, we provide hassle-free returns and exchanges.
Plant Extract Supply keeps a safety stock of more than 300 products, and free samples can be dispatched immediately.
3. Where to Buy
Simply email us at [email protected], or submit your requirements via the form below; we are ready to assist you at any time.
FAQ
Q1: How can I verify product quality before ordering?
A: We can supply existing samples or prepare custom samples according to your specifications and send them for your confirmation.
Q2: What is the minimum order quantity?
A: Typically, the MOQ is 10 grams. For high-value products, it is 1 gram; for low-value products, the MOQ is 100 grams.
Q3: Do you offer discounts?
A: Yes, we provide better pricing for larger quantities.
Q4: How do you handle quality complaints?
A: If a quality issue is confirmed to be our responsibility, we will promptly replace the goods or issue a refund.
Contact us today to request your free Natural Hirudin sample!
